The PICALM gene variant has been identified as a major player in Alzheimer's risk, leading to the formation of aberrant lipid droplets in microglia, the brain's cleanup crew.

Key Insights:

• PICALM allele alters lipid metabolism in microglia.
• Impacts the brain's ability to clear debris, increasing Alzheimer's risk.
• Research sheds light on genetic components of neurodegeneration.

Here's the full scoop.